cerebral mitochondrial oxidative metabolism in a patient with MELAS.
Ikejiri Y, Mori E, Ishii K, Nishimoto K, Yasuda M, Sasaki M.
Division of Clinical Neurosciences Hyogo Institute for Aging Brain and
Cognitive Disorders, Himeji, Japan.
Neurology 1996 Aug;47(2):583-5
We report a 36-year-old man with MELAS in whom a 5-month course of high-dose
oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral
metabolic ratio of oxygen and oxygen extraction fraction without increased
cerebral blood flow with PET. The results indicate that idebenone improves
mitochondrial oxidative metabolism in the brain and suggest a therapeutic
potential of idebenone for MELAS.