administration of idebenone,
a stimulator of NGF synthesis, recovers reduced
NGF content in aged rat brain.
Nitta A, Hasegawa T, Nabeshima T.
Department of Neuropsychopharmacology and Hospital Pharmacy,
School of Medicine, Japan.
Neurosci Lett 1993 Dec 12;163(2):219-22
The relationship between nerve growth factor (NGF) and senile dementia of the
Alzheimer type is of interest. We demonstrate here that the oral
administration of idebenone, a stimulator of NGF synthesis in vitro, produced
recovery of reduced NGF content in aged rat brain. Twenty-one-day successive
administration of idebenone produced significant recovery of reduced NGF
content in the frontal cortex and parietal cortex of aged rats. These results
suggest that NGF content in the brain is low in aged rats and that oral
administration of idebenone leads to a recovery of this reduction