A placebo-controlled study of pyritinol in dementia.

Cooper AJ, Magnus RV.

Pharmatherapeutica 1980;2(5):317-22


A double-blind, placebo-controlled trial was carried out on 40 patients suffering from moderately advanced dementia.  The patients were allocated randomly either pyritinol (800 mg daily) or identical placebo for 3 months. Assessments using a modified Crichton Geriatric Behavioural Rating Scale were made pre-treatment and monthly up to 3 months, and then at follow-up at 6 months.  Patients on pyritinol showed significantly higher levels of improvement than did those on placebo.  Laboratory tests conducted throughout remained within normal limits for both groups

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